Endocrine Abstracts

Introduction: Cryptorchidism, the most frequent congenital malformation in full-term male newborns, increases risk of infertility and testicular cancer. Most cases remain idiopathic but epidemiological and experimental studies have suggested the role of both genetic and environmental factors. Physiological testicular descent is regulated by two major Leydig cell hormones: Insulin-like peptide 3 (INSL3) and testosterone.Methods and results: From a prospec...